Sung K and Jimenez-Sanchez M. Autophagy in astrocytes and its implications in neurodegeneration. J Mol Biol. 2020 Jan 10. [2020 Apr 3;432(8):2605-2621.Review. Click the icon to download the Accepted version of the manuscript

Noble W, Jimenez-Sanchez M, Perez-Nievas BG, Hanger DP. Considerations for future tau-targeted therapeutics: can they deliver? Expert Opin Drug Discov. 2019; 1–3.

Siddiqi FH, Menzies FM, Lopez Ramirez A, Stamatakou E, Karabiyic C, Ureshino R, Ricketts T, Jimenez-Sanchez M, … Rubinsztein DC. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurpusing. Nat Commun.. 2019 Apr 18;10(1):1817

 

Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Füllgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC. Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. Neuron. 2017 Mar 8;93(5):1015-1034. Review

Jimenez-Sanchez M, Licitra F, Underwood BR, Rubinsztein DC.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.  Cold Spring Harb Perspect Med. 2017 Jul 5;7(7). Review

Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC. CCT complex restricts neuropathogenic protein aggregation via autophagy. Nat Commun. 2016 Dec 8;7:13821.

 

Bento CF, Ashkenazi A, Jimenez-Sanchez M and Rubinsztein. The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun 2016 Jun 9;7:11803.

 

Jimenez-Sanchez M and Rubinsztein DC. Huntington’s disease-the sting is in the tail. EMBO J.  2015 Jul 28; 34(17):2215-6. News and Views

 

Jimenez-Sanchez M, Lam W, Hannus M,  Sönnichsen B,  Imarisio S, Fleming A, Tarditi A, Menzies F, Ed Dami T, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F,  Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O’Kane CJ, Caricasole A and Rubinsztein DC. siRNA screen identifies QPCT as a druggable target for Huntington’s disease. Nat Chem Biol. 2015 May;11(5):347-54.

 

Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC. PICALM modulates autophagy activity and tau accumulation. Nat Commun. 2014 Sep 22;5:4998.

 

Zavodszky E, Seaman MN, Moreau K, Jimenez-Sanchez M, Breusegem SY, Harbour ME, Rubinsztein DC. Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. Nat Commun. 2014 May 13;5:3828.

 

Jimenez-Sanchez M*, Menzies F*, Chang YY*, Simecek N, Neufeld TP and Rubinsztein DC. The Hedgehog signalling pathway regulates autophagy. (* Equal contribution to this work). Nat commun. 2012; 3:1200 doi: 10.1038

 

Jimenez-Sanchez, M, Thomson F, Zavodszky E, Rubinsztein DC. Autophagy and polyglutamine diseases. Prog Neurobiol. 2012 May;97(2):67-82. Review

 

Ravikumar, B., S. Sarkar, J.E. Davies, M. Futter, M. Garcia-Arencibia, Z.W. Green-Thompson, M. Jimenez-Sanchez, V.I. Korolchuk, M. Lichtenberg, S. Luo, D.C. Massey, F.M. Menzies, K. Moreau, U. Narayanan, M. Renna, F.H. Siddiqi, B.R. Underwood, A.R. Winslow, and D.C. Rubinsztein. Regulation of mammalian autophagy in physiology and pathophysiology. Physiological Reviews. 2010 Oct; 90(4):1383-435. Review

 

Renna M, Jimenez-Sanchez M, Sarkar S, Rubinsztein DC. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseasesJ Biol Chem. 2010 Apr 9;285(15):11061-7. Review

 

Ravikumar B, Futter M, Jahreiss L, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Narayanan U, Renna M, Jimenez-Sanchez M, Sarkar S, Underwood B, Winslow A, Rubinsztein DC. Mammalian macroautophagy at a glanceJ. Cell Sci. 2009 Jun 1;122(Pt 11):1707-11. Review

Other research publications:

García-González J, Forcén P, Jimenez-Sanchez M. Men and women differ in their perception of gender bias in research institutions. PLoS ONE. 2019;14

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